ILC3s protect intestinal stem cells from chemotherapy

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy.

Recombinant erythropoietin (EPO) analogs [erythropoiesis-stimulating agents (ESA)] are clinically used to treat anemia in patients with cancer receiving chemotherapy. After clinical trials reporting increased adverse events and/or reduced survival in ESA-treated patients, concerns have been raised about the potential role of ESAs in promoting tumor progression, possibly through tumor cell stimu...

متن کامل

Gastrointestinal stem cells. II. Intestinal stem cells.

Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein families in crypt formation are integrated. We ...

متن کامل

Epithelial IKKα licenses ILC3s to defend the intestinal barrier

At last, a mouse model of the natural history of chronic myeloid leukemia (CML) has been elegantly engineered. CML is hardly a public health menace, occurring in only 1–2 per 100,000 people. Nonetheless, the disease is the " poster child " of genetically based diagnosis and treatment, as all cases of CML have the BCR-ABL trans-location, which is both a diagnostic marker of the disease and a tar...

متن کامل

Putative intestinal stem cells

A heterogeneous set of intestinal stem cells markers has been described in intestinal glands but the ultrastructural identity of intestinal stem cells remains unknown. By using electron microscopy, this study demonstrated the presence of cells with stem morphology in the intestinal glands of mice of different ages. These putative intestinal stem cells have large, euchromatic, irregular shaped n...

متن کامل

Intestinal stem cells protect their genome by selective segregation of template DNA strands.

The stem cells in the crypts of the small intestinal mucosa divide about a thousand times during the lifespan of a laboratory mouse, and yet they show little evidence of any decline in proliferative potential and rarely develop carcinogenic mutations, suggesting that their genome is extremely well protected. Protection against DNA-replication-induced errors can be achieved by the selective sort...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 2015

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.21211insight3